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PsychiatryClinical Practice6 min read

Online Sports Betting Legalization and Behavioral Health Care Use

Despite the known behavioral health burdens associated with gambling, little is understood about legalization's impact on mental health and substance use treatment use.

Published in JAMA PsychiatryClinical evidence review
3/5 Observational
Evidence Meter · 3/5

Real-World Observation

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

Source

Real-World Observation

3/5

Results of this quasi-experimental difference-in-differences study suggest that online sports betting legalization was associated with an increase in outpatient and prescription mental health care use among people with employer-sponsored health insurance.

What Changes?

Psychiatry · Clinical Practice

Current Standard

Conventional psychiatry practice relies on standard-of-care monitoring and existing regimens prior to this clinical evidence review.

New Finding

These findings underscore the importance of prevention and treatment of potential adverse health consequences of legalized online sports betting.

3 Key Takeaways

Plain English Summary
  1. 01Core Finding

    To evaluate the association between online sports betting legalization and treatment use for mental health conditions and substance use disorders (SUD).

  2. 02Study Evidence

    Study design used a clinical evidence review protocol to track clinical outcomes.

  3. 03Practical Meaning

    Benefits and risks vary by individual health history — discuss with a healthcare professional.

What This Means for You

Results of this quasi-experimental difference-in-differences study suggest that online sports betting legalization was associated with an increase in outpatient and prescription mental health care use among people with employer-sponsored health insurance. These findings underscore the importance of prevention and treatment of potential adverse health consequences of legalized online sports betting.

The Discovery

The number of states with legal online sports betting has grown from 1 to 31 since 2018, expanding access to gambling. Despite the known behavioral health burdens associated with gambling, little is understood about legalization's impact on mental health and substance use treatment use. To evaluate the association between online sports betting legalization and treatment use for mental health conditions and substance use disorders (SUD). This was a quasi-experimental staggered difference-in-differences study using claims data from January 2016 to December 2023. The setting was a large, national convenience sample of people with employer-sponsored health insurance. Included in the analysis were men and women aged 18 to 64 years living in states that legalized online sports betting during 2018-2022 or had not by the end of the study period. State legalization of online sports betting. Outcomes were measured at the state-year level, weighted by number of enrollees as follows: proportions of enrollees with 1 or more prescription fills for antidepressant, antianxiety, or SUD medications and proportions of enrollees with 1 or more outpatient, emergency department, or inpatient visits with a diagnosis for depression, anxiety, or SUD. Outcomes were measured at the state-year level, weighted by number of enrollees as follows: proportions of enrollees with 1 or more prescription fills for antidepressant, antianxiety, or SUD medications and proportions of enrollees with 1 or more outpatient, emergency department, or inpatient visits with a diagnosis for depression, anxiety, or SUD. Among 61 951 305 enrollee-years, 31 914 852 (52%) were women, and the mean (SD) age was 41.9 (13.5) years. Online sports betting legalization was associated with increases in the probability of antidepressant use (men: 0.57 percentage points; 95% CI, 0.26-0.89 percentage points; women: 1.08 percentage points; 95% CI, 0.23-1.94 percentage points) and antianxiety use (men: 0.32 percentage points; 95% CI, 0.14-0.50 percentage points; women: 0.64 percentage points; 95% CI, 0.16-1.12 percentage points), but there was no detectable change in SUD medication use. Legalization was also associated with increases in the probability of an outpatient diagnosis for depression (men: 0.34 percentage points; 95% CI, 0.20-0.49 percentage points; women: 0.57 percentage points; 95% CI, 0.25-0.89 percentage points) and anxiety (men: 0.67 percentage points; 95% CI, 0.32-1.01 percentage points; women: 1.15 percentage points; 95% CI, 0.50-1.81 percentage points) but not SUD. Legalization was not associated with behavioral health diagnoses in the emergency department and inpatient settings.

How It Works, Simply

This psychiatry research focuses on neurotransmitter circuit & synaptic plasticity modulation. Researchers evaluated it using a standard-of-care clinical practice · Clinical evidence review at the clinical practice stage of medical research.

3 Key Takeaways

Clinical Takeaways
  1. 01Core Finding

    To evaluate the association between online sports betting legalization and treatment use for mental health conditions and substance use disorders (SUD).

  2. 02Study Evidence

    Study design used a clinical evidence review protocol to track clinical outcomes.

  3. 03Practical Meaning

    Benefits and risks vary by individual health history — discuss with a healthcare professional.

01

Biological Mechanism & Study Design

Study Design & Cohort

Clinical evidence review

Standard-of-care clinical practice · Clinical evidence review · Clinical Practice

Biological Pathway & Modality

Neurotransmitter circuit & synaptic plasticity modulation

Intervention: Online Sports Betting Legalization and Behavioral Health Care Use

02

Experimental Findings & Endpoints

The number of states with legal online sports betting has grown from 1 to 31 since 2018, expanding access to gambling.

Despite the known behavioral health burdens associated with gambling, little is understood about legalization's impact on mental health and substance use treatment use. To evaluate the association between online sports betting legalization and treatment use for mental health conditions and substance use disorders (SUD).

This was a quasi-experimental staggered difference-in-differences study using claims data from January 2016 to December 2023. The setting was a large, national convenience sample of people with employer-sponsored health insurance.

Included in the analysis were men and women aged 18 to 64 years living in states that legalized online sports betting during 2018-2022 or had not by the end of the study period. State legalization of online sports betting.

Outcomes were measured at the state-year level, weighted by number of enrollees as follows: proportions of enrollees with 1 or more prescription fills for antidepressant, antianxiety, or SUD medications and proportions of enrollees with 1 or more outpatient, emergency department, or inpatient visits with a diagnosis for depression, anxiety, or SUD. Outcomes were measured at the state-year level, weighted by number of enrollees as follows: proportions of enrollees with 1 or more prescription fills for antidepressant, antianxiety, or SUD medications and proportions of enrollees with 1 or more outpatient, emergency department, or inpatient visits with a diagnosis for depression, anxiety, or SUD.

Among 61 951 305 enrollee-years, 31 914 852 (52%) were women, and the mean (SD) age was 41.9 (13.5) years. Online sports betting legalization was associated with increases in the probability of antidepressant use (men: 0.57 percentage points; 95% CI, 0.26-0.89 percentage points; women: 1.08 percentage points; 95% CI, 0.23-1.94 percentage points) and antianxiety use (men: 0.32 percentage points; 95% CI, 0.14-0.50 percentage points; women: 0.64 percentage points; 95% CI, 0.16-1.12 percentage points), but there was no detectable change in SUD medication use.

Legalization was also associated with increases in the probability of an outpatient diagnosis for depression (men: 0.34 percentage points; 95% CI, 0.20-0.49 percentage points; women: 0.57 percentage points; 95% CI, 0.25-0.89 percentage points) and anxiety (men: 0.67 percentage points; 95% CI, 0.32-1.01 percentage points; women: 1.15 percentage points; 95% CI, 0.50-1.81 percentage points) but not SUD. Legalization was not associated with behavioral health diagnoses in the emergency department and inpatient settings.

03

Clinical Translation & Practice Context

Results of this quasi-experimental difference-in-differences study suggest that online sports betting legalization was associated with an increase in outpatient and prescription mental health care use among people with employer-sponsored health insurance.

These findings underscore the importance of prevention and treatment of potential adverse health consequences of legalized online sports betting.

03

The Bottom Line · Clinical Pearl

“Results of this quasi-experimental difference-in-differences study suggest that online sports betting legalization was associated with an increase in outpatient and prescription mental health care use among people with employer-sponsored health insurance.”

Published in JAMA Psychiatry · Current Stage: Clinical Practice

Psychiatry · Clinical Practice
Study Type
Clinical evidence review

Standard-of-care clinical practice · Clinical evidence review

Evidence Score
3/5 · Real-World Observation
Evidence Meter · 3/5

Real-World Observation

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

Who It Applies To
Standard-of-care clinical practice · Clinical evidence review in psychiatry care
Intervention & Mechanism
Online Sports Betting Legalization and Behavioral Health Care Use

Neurotransmitter circuit & synaptic plasticity modulation

Key Limitation
Benefits and risks vary by individual health history — discuss with a healthcare professional.

Translational Stage

LEVEL 1 · Clinical Practice

Classified as Clinical evidence review along the clinical evidence continuum

  1. Lab & Discovery
  2. Early Trials
  3. Human Evidence
  4. 4Clinical PracticeActive

Indexed Clinical Entities

Original Publication & AMA Citation

Online Sports Betting Legalization and Behavioral Health Care Use. JAMA Psychiatry. Published 2026;Oct 14. Accessed November 15, 2026. https://pubmed.ncbi.nlm.nih.gov/42873510/

JAMA Psychiatry

https://pubmed.ncbi.nlm.nih.gov/42873510/

Read Original Paper

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