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Hashimoto's thyroiditis: two decades on

This Review synthesises developments over the past two decades in the epidemiology, natural history, aetiopathogenesis, diagnosis, and management of Hashimoto's thyroiditis, and considers emerging mechanistic insights and approaches to precision medicine that might inform future disease-modifying therapies. Management centres on levothyroxine replacement for overt hypothyroidism, with an individualised approach to subclinical disease.