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Estimating GFR: what it is, what it is not, and why prediction cannot settle the question

Equations are population tools; at the bedside, non-glomerular filtration rate determinants of both creatinine and cystatin C can mislead. Schultheiss et al. show that replacing Chronic Kidney Disease Epidemiology Collaboration with European Kidney Function Consortium cystatin C-based equations reclassifies women, but not men, into milder chronic kidney disease stages, while outcome prediction is unchanged.