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Granzyme K is a driver of age-related tissue remodeling and functional decline independently of age-associated immune dysfunction

These findings identify GzmK as a tissue-specific driver of organismal aging but not immune aging or systemic inflammaging. In the kidney, this was associated with reduced complement deposition, whereas in the liver, improved function and reduced fibrosis (tissue scarring) occurred independently of complement, coinciding instead with increased decorin and reduced pro-fibrotic TGF-β signaling.