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ClearMed Editorial Digest500 briefings across 12 specialties121 Phase III & clinical practice

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Psychiatry

Psychiatry Clinical Briefings

Peer-Reviewed Clinical Digests · Verified Scientific Media

PSYCHIATRY · REAL-WORLD COHORT

From discovery to proof: a Translation Evidence Map for precision psychiatry

The Personal View discusses examples spanning inflammatory and circuit-based depression stratification, psychosis relapse monitoring, and suicidality monitoring, illustrating how the Map makes claim maturity, stopping points, stakeholder roles, and trade-offs important to patients explicit. Precision psychiatry aims to improve individual-patient decisions by measuring clinically meaningful heterogeneity, not by privileging any one data type, biomarker (measurable biological signal), or analytical method.

3/5 Observational

Evidence Meter · 3/5

Real-World Observation

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

1 min readThe Lancet PsychiatryNov 5, 2026

PSYCHIATRY · REAL-WORLD COHORT

Serum selenium, iron and rubidium are altered in treatment-resistant schizophrenia

Further research should investigate the relationship between peripheral and central measures of these elements and their metabolism, and further explore the relevance of pro-oxidant stress to the neuropathology of schizophrenia. The changes in serum iron, rubidium and selenium discriminate between control individuals and TRS cases, and they were not affected by age or clozapine serum levels.

3/5 Observational

Evidence Meter · 3/5

Real-World Observation

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

1 min readMolecular PsychiatryNov 2, 2026

PSYCHIATRY · REAL-WORLD COHORT

Dynamic epigenetic changes during antidepressant pharmacotherapy in major depressive disorder

This study provides first longitudinal evidence of regionally coordinated DNA methylation changes during antidepressant pharmacotherapy, revealing alterations in genes involved in neuroplasticity and inflammatory processes that are associated with clinical response. Baseline methylation levels were associated with depressive symptom severity at day 28 and day 56 through two and six DMRs, respectively (e.g., TNRC6C, CAT), whereas no single DMP reached significance.

3/5 Observational

Evidence Meter · 3/5

Real-World Observation

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

1 min readMolecular PsychiatryNov 2, 2026

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