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ClearMed Editorial Digest500 briefings across 12 specialties121 Phase III & clinical practice

Indexed from PubMed, NEJM, The Lancet, JAMA, Nature MedicineSaved Library

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Showing 5 briefings matching “inflammation”

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Endocrinology

Endocrinology Clinical Briefings

Peer-Reviewed Clinical Digests · Verified Scientific Media

ENDOCRINOLOGY · REAL-WORLD COHORT

Opposing microbiome-mediated axes link modifiable lifestyles to health and chronic diseases

We identify the gut microbiome as a key mediator linking lifestyle to health and disease, providing a framework for microbiome-based assessment to guide lifestyle interventions for health promotion and disease prevention. Microbiome-defined health- and disease-oriented mediator axes were supported by fecal short-chain fatty acids and plasma cytokines from >1,700 individuals, revealing butyrate-associated anti-inflammatory and pro-inflammatory host profiles, respectively.

3/5 Observational

Evidence Meter · 3/5

Real-World Observation

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

1 min readNature MedicineNov 5, 2026

ENDOCRINOLOGY · CLINICAL PRACTICE

Lipid organization in health and disease

In this Voices piece, our authors explore these themes through specific examples. Lipids are spatially and dynamically organized-within organelles, across cell types and organs, and in response to microbial and dietary inputs.

3/5 Observational

Evidence Meter · 3/5

Real-World Observation

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

1 min readCell MetabolismNov 3, 2026

ENDOCRINOLOGY · CLINICAL PRACTICE

Histone lactylation scarring transmits metabolic and epigenetic memory across the gut-liver axis

Together, our findings define H3K9la-centered macrophage memory as a mobile pathogenic imprint that links prior colitis to increased susceptibility to metabolic liver disease. Myeloid-specific Smarca4 deletion or pharmacological interruption of macrophage trafficking attenuates macrophage memory and protects against MASLD.

3/5 Observational

Evidence Meter · 3/5

Real-World Observation

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

1 min readCell MetabolismNov 3, 2026

ENDOCRINOLOGY · PRECLINICAL

A context-dependent framework for targeting NAD metabolism in cancer

Here, we critically review the rewiring of NAD metabolism in cancer, associated therapeutic opportunities, and barriers to their clinical exploitation. Importantly, the dependence of malignant cells on sustained NAD availability constitutes a therapeutically exploitable vulnerability.

2/5 Preclinical

Evidence Meter · 2/5

Animal & Preclinical Data

Demonstrated in living animal models before large-scale human safety and dosing trials begin.

1 min readCell MetabolismOct 15, 2026

ENDOCRINOLOGY · REAL-WORLD COHORT

Hashimoto's thyroiditis: two decades on

This Review synthesises developments over the past two decades in the epidemiology, natural history, aetiopathogenesis, diagnosis, and management of Hashimoto's thyroiditis, and considers emerging mechanistic insights and approaches to precision medicine that might inform future disease-modifying therapies. Management centres on levothyroxine replacement for overt hypothyroidism, with an individualised approach to subclinical disease.

3/5 Observational

Evidence Meter · 3/5

Real-World Observation

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

1 min readThe Lancet Diabetes & EndocrinologyOct 7, 2026

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