Sunday, November 15, 2026

Peer-Reviewed Clinical Evidence Platform

The research that matters, without the jargon.

Peer-reviewed breakthroughs in plain English alongside verified outcomes, evidence grades, and clinical study details for everyone from everyday readers to medical students.

ClearMed Editorial Digest500 briefings across 12 specialties121 Phase III & clinical practice

Indexed from PubMed, NEJM, The Lancet, JAMA, Nature MedicineSaved Library

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Showing 6 briefings matching “diabetes”

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Cardiology

Cardiology Clinical Briefings

Peer-Reviewed Clinical Digests · Verified Scientific Media

CARDIOLOGY · REAL-WORLD COHORT

Daily Avocado & Mango: New Heart Health Allies?

Daily intake of avocado and mango may positively impact blood vessel health and diastolic blood pressure, offering a simple dietary intervention for cardiovascular well-being. This research suggests a simple, nutrient-rich dietary adjustment could offer a straightforward way to support cardiovascular health, especially for at-risk populations like those with prediabetes.

3/5 Observational

Evidence Meter · 3/5

Real-World Observation

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

1 min readScienceDailyNov 12, 2026

CARDIOLOGY · PHASE III

Coronary Artery Calcium Scoring Challenges Traditional Statin Prescription Guidelines

Coronary Artery Calcium (CAC) guided statin initiation resulted in similar major cardiovascular event rates with fewer prescriptions and significantly improved patient adherence compared to traditional risk assessments. Current standard of care for primary prevention statin initiation heavily relies on calculated risk scores (e.g., ASCVD risk in the US), which estimate the 10-year risk of atherosclerotic cardiovascular disease events based on factors like age, sex, race, cholesterol levels, blood pressure, and diabetes status.

5/5 Gold Standard

Evidence Meter · 5/5

Gold-Standard Human Evidence

Backed by randomized controlled human trials or a formal meta-analysis pooling multiple clinical studies.

1 min readScienceDailyNov 12, 2026

CARDIOLOGY · PHASE III

Coronary Artery Calcium Scoring: A New Paradigm for Statin Allocation and Adherence?

Using coronary artery calcium (CAC) scoring to guide statin initiation reduces statin prescriptions without compromising major cardiovascular event prevention, while significantly improving medication adherence. Current guidelines from bodies like the ACC/AHA primarily utilize traditional risk assessment tools, such as the Pooled Cohort Equations, to identify individuals at intermediate to high risk for atherosclerotic cardiovascular disease (ASCVD) who would benefit from statin therapy.

5/5 Gold Standard

Evidence Meter · 5/5

Gold-Standard Human Evidence

Backed by randomized controlled human trials or a formal meta-analysis pooling multiple clinical studies.

1 min readScienceDailyNov 12, 2026

CARDIOLOGY · RANDOMIZED CLINICAL TRIAL

First and Subsequent Major Cardiovascular Events With Oral Semaglutide in High-Risk Type 2 Diabetes: A Secondary Analysis of the SOUL Randomized Clinical Trial

Oral semaglutide reduced the risk of first plus subsequent 3-P MACE vs placebo (inactive comparison treatment), highlighting the benefit of oral semaglutide in reducing the total burden of clinical morbidity and risk of death in this high-risk population. This was a prespecified secondary analysis of the double-blind, placebo-controlled, event-driven, phase 3b SOUL randomized clinical trial, conducted from June 2019 to September 2024 with a median (IQR) follow-up of 49.5 (44.0-54.9) months at 444 centers in 33 countries.

5/5 Gold Standard

Evidence Meter · 5/5

Gold-Standard Human Evidence

Backed by randomized controlled human trials or a formal meta-analysis pooling multiple clinical studies.

1 min readJAMA CardiologyNov 11, 2026

CARDIOLOGY · RANDOMIZED CLINICAL TRIAL

Left Atrial Appendage Closure in Patients Considered Unsuitable for Oral Anticoagulation: Randomized Outcomes Through 5 Years in ASAP-TOO

In this prematurely terminated and underpowered trial, LAAC implantation was successful, with acceptable safety. Long-term estimates with LAAC were numerically favorable for thromboembolism but imprecise, while early bleeding was increased with the mandated antiplatelet regimen.

5/5 Gold Standard

Evidence Meter · 5/5

Gold-Standard Human Evidence

Backed by randomized controlled human trials or a formal meta-analysis pooling multiple clinical studies.

1 min readJournal of the American College of CardiologyOct 31, 2026

CARDIOLOGY · REAL-WORLD COHORT

Cortisol in cardio-kidney-metabolic disease

This review will serve as a practical guide for cardiologists to manage a potentially reversible contributor to poor CKM control. Therapeutic strategies include adrenal steroidogenesis inhibitors, glucocorticoid receptor antagonists, and pituitary-directed therapies in selected cases, while surgery remains the first-line treatment for surgically remediable disease.

3/5 Observational

Evidence Meter · 3/5

Real-World Observation

Finds meaningful patterns in human health records or cohorts, though observational data cannot prove direct cause.

1 min readEuropean Heart JournalOct 28, 2026

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